Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
HEC Paris is not ranked first in any of the individual criteria but registered a strong performance throughout. Its alumni have the fifth-highest salaries three years after graduation at $93,000 and the programme is ranked third for value for money and the international mobility of its alumni. The school also shares the highest score — 93 per cent — for aims achieved.
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
不过，在长达四小时的马拉松般的颁奖典礼中，《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯（Barry Jenkins，文首图中）和塔雷尔?阿尔文?麦克拉尼（Tarell Alvin McCraney，文首图右）获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖，这是美国穆斯林男演员首位获得奥斯卡奖。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Local residents living near the launch sites have complained that the activists are putting their lives at risk by making them potential targets for North Korean retaliation.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
"China is Australia's most valuable tourism market, with the potential to be worth more than $13 billion by 2020."
May your New Year be filled with special moment, warmth, peace and happiness, the joy of covered ones near, and wishing you all the joys of Christmas and a year of happiness.愿你的新年充满温馨，祥和，与亲人团聚的快乐，祝乐陶陶，新年乐无限。
Trends and targets in antiviral phototherapy
John Hummel, chief investment officer for AIS Group, a fund manager with $400 million under management, said all the new sources of global oil are expensive to extract, and he sees U.S. shale output falling by 2015.
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
Technically it is a project of the 10-member Association of Southeast Asian Nations to bring all of its trade deals in the region under one umbrella. It also lacks the ambition on many fronts of the TPP.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Busting through the glass ceiling
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
"We have a system here in America where if something is for you and if they find it, it gets to you, that's beautiful," he told US TV station WTAE.
ACE2 as a potential therapeutic target for pandemic COVID-19
6. The 2012 Ig Nobel Prize for Literature
Diagnostic technologies for COVID-19: a review
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Mr. Sissako is both an indispensable political filmmaker and one of the great poets of contemporary cinema. His portrait of life under jihadi rule in northern Mali is brutal and shocking, but also gentle, generous and surprisingly funny. Mr. Sissako does not humanize violent extremists so much as demonstrate that they already belong to the species and reflect part of our common, tragic nature. But his movie also insists that the only effective and ethically serious way to oppose fanaticism is with humanism. Which is to say with irony, with decency and, perhaps above all, with art. (Read the review.)
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
7. Smart cookie oven
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
The app D'Aloisio designed, Summly, compresses long pieces of text into a few representative sentences. When he released an early iteration, tech observers realized that an app that could deliver brief, accurate summaries would be hugely valuable in a world where we read everything-from news stories to corporate reports-on our phones, on the go. The app attracted the interest of investors around the world, ranging from Hollywood celebrities to Hong Kong billionaire Li Ka-shing, the wealthiest man in Asia.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Comedy Series: “Veep” (HBO)
Antiviral drug discovery: broad-spectrum drugs from nature
7. Smart cookie oven
中国旅游研究院国际旅游研究所(Institute of International Tourism)副所长蒋依依认为，外国游客数量下降的部分原因在于人民币的升值。
Influenza neuraminidase: A druggable target for natural products
Despite the breakthrough, Jack Ma, chairman of Alibaba Group, said there was no need for human beings to fear machines.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Do you routinely roll your eyes? Do you have a weak handshake? Do you avoid making eye contact? These could all be career killers. People must understand that actions speak louder than words. And the majority of our communication is done through non-verbal cues. People could perceive some of your non-verbal communication habits as rude or unprofessional—and these things could eventually have a significant impact on the advancement of your career.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
During the RoboCup 2500 contestants from 40 countries competed in 15 competitions with various types of computerized soccer robots, healthcare robots, rescue robots and dance robots.
Last year, the CPI increase peaked at 2.5 percent in January, and later fluctuated below 2 percent during the rest of the year.
Based on a new estimate provided by the government of Dubai, its visitor spending of $31.3 billion this year far exceeds London's estimated $19.8 billion, which comes second.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Apple CEO Tim Cook
Since you will be spending so much time in your office space, you should be comfortable enough to enjoy what you do. A comfy chair will keep you pleased throughout the day. We recommend the Allak Swivel Chair, $59.99, at Ikea.com. If you need music to keep your mind stirring, we recommend the Sound System iPod Speaker, $220, at UrbanOutfiters.com.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
5. Google Webmaster Tools.
Inhibition of SARS coronavirus helicase by bismuth complexes
The booming Internet economy now is playing an increasingly important role in supporting wealth growth in China's IT industry.
The first selfie stick was invented long before the first handheld mobile device was made. A selfie stick was definitely invented by the Japanese man Hiroshi Ueda in the 1980s. A photographer and worker at the Minolta camera company, Hiroshi made the selfie stick because he and his wife were unable to take pictures of themselves during a trip to Europe. (When he asked a boy to take pictures of them, the boy ran off with the camera.)
全食CEO约翰麦基的《自觉资本主义》（Conscious Capitalism）一书让公司高管们不得不思考这样一个观点，那就是处于最佳运转状态的企业能为所有利益相关方创造价值，而不仅仅是投资者。麦基认为，主要利益相关方包括顾客、员工、供应商、社会以及环境。他以好市多、西南航空（Southwest Airlines ，《财富》500强）和谷歌（Google，《财富》500强）为例，说明思维超越利润能够打造更强大而、更高效的公司。
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
11. 《黑豹党：革命先锋》(The Black Panthers: Vanguard of the Revolution)，导演：斯坦利?尼尔森(Stanley Nelson)。
The big winners over the past year in Arizona were the construction and leisure/hospitality industries, which both added more than 10, 000 jobs. Other fast-growing sectors include business services, financial activities and education and health services.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
根据中国海关总署(General Administration of Customs)发布的数据，12月份以美元计的出口额同比减少6.1%至2094.2亿美元。这一跌幅比经济学家预期的中数多了2.1个百分点，也大于11月份修正后1.6%的跌幅（修正前该数字为增长0.1%）。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
8. Smile every time EXCEPT when my team is losing.
And, at random, some other highlights from the list:
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
With Westbrook playing such a hands-on, high-usage role and Victor Oladipo already locked in on a high-dollar extension, Payne needed to prove he could be an off-ball threat or a lead guard on the second unit.
4. Smart trashcan
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The computer is a very powerful machine built with ARM processors, the kind low-power processors that run smartphones and tablets. These servers allow more computing power o be packed into a smaller space. And that has big implications for building green-but-powerful data centers."I think of myself as an entrepreneur besides just being an electrical engineer. I believe what I'm doing can have a major effective on the world," Sohmers said.He dropped out of high school to join Peter Thiel's controversial startup accelerator, the 20 Under 20 Thiel Fellowship. Thiel, the former PayPal CEO and famous Silicon Valley venture capitalist known for his early investment in Facebook, is a libertarian who has often spoken out about the absurd cost of college these days.So in 2011, he started a program that encourages kids to start companies instead of going to college. It gives them $100,000 in seed money and access to some of the Valley's greatest technologists as mentors.Sohmers is an electrical engineering prodigy who at age 13 started working at the research lab at MIT. That's where he met his co-founder and CTO, Keville, he said.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Happy new year, my best friend.祝我的挚友新年快乐。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
NeXT 电脑公司总裁兼CEO史蒂夫乔布斯在向公众展示他的新一代NeXT 工作站（此时乔布斯已经离开苹果创办了皮克斯动画和NeXT 电脑公司），1990年9月18日，旧金山
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
4．The Mask Of Zorro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Ahead of the release, economists at ANZ said they expected inflation to pick up in January owing to rising food prices, and the low commodity prices would weigh on the CPI.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
When it comes to diversity, I am optimistic that at some point the rise of enlightened younger executives will trigger a sudden change of attitude in the boardroom. This will not happen in 2018, though the imbalances and abuses of power evident in sexual harassment scandals, from tech to media, could accelerate change.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
'I think South Korea has a very rigorous and narrow definition of beauty because we’re an ethnically homogenous society and everyone looks pretty much the same. It is also related to low self-esteem.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Swyft有50家短信应用合作伙伴，包括Kakao Talk, Facebook Messenger, BlackBerry Messenger和 Line。这种合作让这家只有11个人的小公司能接触到25亿注册用户。随着利用短信应用赚钱的办法不断演化，这家年轻的创业公司已探索出一条可让各大品牌挤进人们聊天领域的生财之道。（财富中文网）
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
在被问及欧洲央行会不会采取更多行动时，朗伯德街研究(Lombard Street Research)首席欧洲经济学家达里奥·铂金斯(Dario Perkins)表示：“我不这么认为——除非全球整体经济出了问题。”
You know the old guy who's been at the company forever and still can't figure out email? If you don't get up to speed on social media in 2014, you'll be that guy. Compared to last year, there are 13 times as many jobs advertised on Indeed.com that mention the use of social media. "We are seeing an increased demand for social savvy candidates across the business -- from human resources to product to customer service, " Amy Crow, Indeed's communication director told Quartz earlier this year. Not only are departments like marketing, sales, and customer service expected to be on Twitter (TWTR) and Facebook, teams as diverse as R&D, logistics, and HR are increasingly using internal networks like Yammer to streamline operations. Social media has grown so critical to the workplace, in fact, that major universities are beginning to offer certificate programs for socially inept corporate types to get up to speed.
The immediacy for a larger-screen iPhone comes partially from the Asian market where Samsung’s phablets have made significant inroads. Assuming that Apple’s agreement with China Mobile includes these upcoming products, the pricing adjustments that normally occur with new iPhones could make the iPhone 5C significantly more affordable and attractive to the Chinese market. This would begin to make sense of the 5C, which so far seems to be a sales disappointment for Apple. Perhaps the important thing about the 5C is that it is not the 5S, so that down the road it can be discounted without putting price pressure on Apple’s flagship.
A modular microarray imaging system for highly specific COVID-19 antibody testing
The pair stand on opposite sides backstage and memorize the winners to avoid having to write them down and have revealed in the past how they carry out rigorous checks to ensure they have stuffed the envelopes correctly. It is believed Ruiz and Cullinan are ordered to destroy the duplicate cards as the presentation goes on, so by the time Best Picture is awarded, the only envelopes left are the two for Best Picture.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Second, McDermott, a career 39.9% three-point shooter, addresses Oklahoma City's biggest roster weakness—a lack of perimeter options around Russell Westbrook—and remains on a bargain rookie deal through the end of next season.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
1. Hokkaido, Japan-Though known primarily to the outside world for its ski resorts and powdery snow, Hokkaido's year-round beauty might soon become a more familiar sight to foreign visitors. The new bullet-train service from Tokyo should help.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
中国旅游研究院国际旅游研究所(Institute of International Tourism)副所长蒋依依认为，外国游客数量下降的部分原因在于人民币的升值。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
《火线警探》，FX，1月20日。副警长瑞兰·吉文斯（Raylan Givens，蒂莫西·奥利芬特[Timothy Olyphant]饰）与他的朋友兼天敌博伊德·克劳达（Boyd Crowder，沃尔顿·戈金斯[Walton Goggins]饰）之间爱恨交织的关系贯穿了整部剧，不管怎样，这个问题将在第六季，也就是最终季中得到最终解决。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
According to the study, 75% of consumers are aware of wearable technology (whether as futuristic fashion or new-age tech tool), but only 9% actually have any interest in wearing it. A meager 2% admitted to owning a wearable tech device, most of which consist of fitness trackers and smart watches, according to the study.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Barney Thompson is legal correspondent
Thirty-six Chinese brands have made it onto the list this year. Among them, eight are in the top 100, including the State Grid Corporation of China (36), the Industrial and Commercial Bank of China (ICBC) (40), Tencent (43), China Central Television (CCTV) (62), Haier (76), China Mobile (79), Huawei (81) and Lenovo (90).
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Intel welcomes its new employees to the company by rolling out the red carpet -- literally -- once a quarter. During the first day of orientation, hires walk along a pathway lined with Intel Studios' photographers and videographers before introducing themselves onstage and receiving their welcome packages (and a round of applause from an audience of new colleagues).
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Although no North American cities feature in the top 20, the EIU said the cost of living in New York had risen relative to other places in the United States. It shares 27th position as the most expensive US city with Los Angeles.
Elsewhere, Stockholm School of Economics was a big winner, climbing 16 places to 28, not only recording the best year-on-year progression but also recovering from a drop of 11 places last year.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
My hunch is that this draft will look pretty good by March and will be much better than last year's, which was one of the most underwhelming in recent memory. New Orleans and Washington both need some direction, and soon.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The first wearable computer glasses were made by Edward Thorp and Claude Shannon in 1961. In 1968, Ivan Sutherland made the "Sword of Damocles." It was the first head-mounted computer display and an early variant of all wearable computer glasses we have today. In 1980, Steve Mann, known today as the father of wearable computing, made the "WearComp", a pair of tech-enhanced glasses that was capable of communicating wirelessly with other computers and could share videos. He continued to work on the glasses over the years, and by 1999, he had come up with a pair of glasses that looked like Google Glass, or rather, that Google Glass looks like. He called it the "EyeTap."
1号 what the fuck: “职场辣妈”的新境界
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
凯特·温斯莱特（Kate Winslet）是另一位将其最佳女演员奖杯置于洗手间的英国演员。她因在2008年一部改编自本哈德·施林克(Bernhard Schlink)的小说《生死朗读》(The Reader)的同名影片中扮演一位集中营的看守而获此殊荣。
Anti-HIV drug repurposing against SARS-CoV-2
Christie’s biannual evening sale on Dec. 8 raised just 6.5 million pounds with fees, about $9.7 million, against a low estimate of 12.7 million. Nineteen of the 45 works, or 42 percent, failed to sell, including the two most highly valued lots — a 1582 watercolor study of a hare among plants by Hans Hoffmann, a pupil of Albrecht Dürer, and a fine 1770s Francesco Guardi view of the island of San Giorgio Maggiore in Venice, carrying low estimates of 4 million and 1.5 million respectively.
First, says Tom Kozenski, a supply-chain expert at consulting and training firm RedPrairie, most people still think of logistics -- if they think of it at all -- as a "non-sexy" field centered on boring, low-paid warehouse work.
Length-scale dependence of protein hydration-shell density
Yet there are similarities between the demagogic elements of the Brexit campaign and the rise of Mr Trump.
它被广泛误解为一部关于小说家大卫·福斯特·华莱士(David Foster Wallace)的传记电影，其实庞索特的这部影片是一部关于新闻的坏方法的喜剧，以及对文学名誉机制充满了解的辛酸讽刺。杰西·艾森伯格(Jesse Eisenberg)与杰森·西格尔(Jason Segel)使用“男人老友电影”(buddy movie)的传统方式，完美地呈现出一个新的子类：亦敌亦友电影。
The incomes of graduates from universities listed in China's 211, or 985 key university national projects are far ahead of those from ordinary universities, the survey found.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
?Bond has a keen eye for who to trust and who not to. This quality is frequently seen in sexually open-minded people, actually. 007 can tell when a lady is into him. And science agrees: handsome men are the best at identifying who is attracted to them.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Currency movements have had a strong impact on agricultural commodity prices this year, with the UK’s referendum on the EU leading to a sharp fall in the pound that pushed up the price of food imports and boosted agricultural exports.
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